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Employer: Royal College of Surgeons in Ireland

Location: Dublin, Ireland

Type: PhD Studentship

Posted: July 15, 2010

Expires: September 13, 2010

A Ph.D. Studentship in the laboratory of Prof. Nikolaus Plesnila and funded through a Science Foundation Ireland Principle Investigator award is available for commencement in October. The stipend for this position is €18,000 per annum.

We are interested in hearing from highly-motivated and enthusiastic science graduates who wish to pursue a Ph.D. and a career in biomedical sciences and imaging, with a strong translational medical research basis.

Project title: In vivo imaging characterisation of inflammatory response following TBI

Background: Traumatic brain injury (TBI) consists of two phases: an immediate phase in which damage is caused as a direct result of the mechanical impact; and a late phase of altered biochemical events that results in delayed tissue damage during which therapeutic intervention is possible. Amongst other factors, a strong inflammatory reaction takes place which may contribute to the secondary brain damage.

Objective: The first part of the project will be to evaluate the time course and number of inflammatory cells adhering to the cerebrovascular endothelium in deep brain vessels after traumatic brain injury. This will be investigated in vivo by multi-photon microscopy. In the second part of the project the student will a) monitor the effect of various drugs on leukocyte-endothelial interaction in vivo and b) determine their effect on secondary brain damage via histology and functional outcome.

Reference:
Schwarzmaier SM, Kim SW, Trabold R, Plesnila N. Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice. Neurotrauma. 2010 Jan;27(1):121-30.

Interested candidates are invited to send a C.V., a brief cover letter indicating their specific interests, and a list of up to three references, prior to the 2nd August 2010 via e-mail.

Visit NatureJobs.com to submit an application.

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